Description
PIPRATAZ INJECTION
PIPRATAZ INJECTION is a brand of Piperacillin & Tazobactum.
Piperacillin, a broad spectrum, semi-synthetic penicillin active against many Gram-positive and Gram-negative aerobic and anaerobic bacteria, exerts bactericidal activity by inhibition of both septum and cell wall synthesis.
Tazobactam extends the antibiotic spectrum of piperacillin to include many beta-lactamase producing bacteria that have acquired resistance to piperacillin alone.
Composition
Each vial of PIPRATAZ 4.5 G contains:
Piperacillin sodium USP equivalent to Piperacillin ………… 4.0g
Tazobactam sodium USP equivalent to Tazobactam ……….. 0.5g
Indications:
- Piperacillin/Tazobactam is indicated for the treatment of the following infections in adults and children over 2 years of age.
Adults and Adolescents –
– Severe pneumonia including hospital-acquired and ventilator-associated pneumonia
– Complicated urinary tract infections (including pyelonephritis)
– Complicated intra-abdominal infections
– Complicated skin and soft tissue infections (including diabetic foot infections)
– Treatment of patients with bacteremia that occurs in association with, or is suspected to be associated with, any of the infections listed above.
– Piperacillin/Tazobactam may be used in the management of neutropenic patients with fever suspected to be due to a bacterial infection. - Children 2 to 12 years of age –
– Complicated intra-abdominal infections
– Piperacillin/Tazobactam may be used in the management of neutropenic children with fever suspected to be due to a bacterial infection.
METHOD OF ADMINISTRATION:
Piperacillin/Tazobactam 4 g/0.5 g for solution is administered by intravenous infusion (over 30 minutes).
PRESENTATION:
1 vial of Piprataz 4.5 g (Dry powder for injection)
SHELF LIFE
24 months for unopened vial. After reconstitution, chemical and physical in-use stability of diluted infusion solutions has been demonstrated for 24 hours at 25°C and for 48 hours when stored in a refrigerator at 2- 8°C, when reconstituted using one of the compatible solvents for further dilution of the reconstituted solution at the suggested dilution volumes. From a microbiological point of view, the reconstituted and diluted solutions should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 12 hours at 2-8°C, unless reconstitution and dilution have taken place in controlled and validated aseptic conditions.
STORAGE
Store below 30°C. Protect from light. Keep out of reach of children.
